Piezo1 suppression reduces demyelination after intracerebral hemorrhage
Jie Qu 1, Hang-Fan Zong 2, Yi Shan 1, Shan-Chun Zhang 3, Wei-Ping Guan 3, Yang Yang 4, Heng-Li Zhao 3
Piezo1 is really a robotically-gated calcium funnel. Recent reports have proven that Piezo1, a robotically-gated calcium funnel, can attenuate both psychosine- and lipopolysaccharide-caused demyelination. Because oligodendrocyte damage and demyelination exist in intracerebral hemorrhage, within this study, we investigated the function of Piezo1 in intracerebral hemorrhage. We established a mouse type of cerebral hemorrhage by injecting autologous bloodstream in to the right basal ganglia and located that Piezo1 was largely expressed soon (within 48 hrs) after intracerebral hemorrhage, mainly in oligodendrocytes. Intraperitoneal injection of Dooku1 to hinder Piezo1 led to marked alleviation of brain edema, myelin sheath loss, and degeneration in hurt tissue, a considerable decrease in oligodendrocyte apoptosis, along with a significant improvement in nerve function. Additionally, we discovered that Dooku1-mediated Piezo1 suppression reduced intracellular endoplasmic reticulum stress and cell apoptosis with the PERK-ATF4-CHOP and inositol-requiring enzyme 1 signaling path. These bits of information claim that Piezo1 is really a potential therapeutic target for intracerebral hemorrhage, since it’s suppression reduces intracellular endoplasmic reticulum stress and cell apoptosis and protects the myelin sheath, therefore improving neuronal function after intracerebral hemorrhage.